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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TERT All Species: 27.27
Human Site: Y18 Identified Species: 50
UniProt: O14746 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14746 NP_937983.2 1132 126997 Y18 R S L L R S H Y R E V L P L A
Chimpanzee Pan troglodytes XP_001141663 1135 126922 Y18 R S L L R S H Y R E V L P L A
Rhesus Macaque Macaca mulatta XP_001096904 1132 126842 Y18 R S L L R S R Y R E V L P L A
Dog Lupus familis XP_851664 1092 121456 Y18 R A L L R G R Y R E V L P L A
Cat Felis silvestris
Mouse Mus musculus O70372 1122 127960 Y18 R S L L R S R Y R E V W P L A
Rat Rattus norvegicus Q673L6 1125 126915 Y18 R S L L R S R Y R E V W P L A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001026178 1346 155264 Y34 L G A L R G C Y A E A T P L E
Frog Xenopus laevis NP_001079102 1191 137998 Y18 L S I L Q R L Y G Q V L G I V
Zebra Danio Brachydanio rerio NP_001077335 1098 125968 Y22 L E I L R S L Y P V V Q T L E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_781093 1312 150053 F92 K N V L L N G F T S W R S E G
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001105870 1188 135970 G29 G A L A R T L G H A V L S L I
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_197187 1123 130561 G18 E I L W R L F G N R A R N L N
Baker's Yeast Sacchar. cerevisiae Q06163 884 102645
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.1 95.8 70.3 N.A. 63.3 63.3 N.A. N.A. 45.2 42.9 32.8 N.A. N.A. N.A. N.A. 27
Protein Similarity: 100 97.9 97.4 77.5 N.A. 74 73.5 N.A. N.A. 58.2 60.1 50.8 N.A. N.A. N.A. N.A. 42
P-Site Identity: 100 100 93.3 80 N.A. 86.6 86.6 N.A. N.A. 40 33.3 40 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 100 93.3 86.6 N.A. 86.6 86.6 N.A. N.A. 40 60 46.6 N.A. N.A. N.A. N.A. 40
Percent
Protein Identity: N.A. 24.7 N.A. 24.8 20.7 N.A.
Protein Similarity: N.A. 40.4 N.A. 42.6 36.9 N.A.
P-Site Identity: N.A. 33.3 N.A. 20 0 N.A.
P-Site Similarity: N.A. 46.6 N.A. 20 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 16 8 8 0 0 0 0 8 8 16 0 0 0 47 % A
% Cys: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 8 8 0 0 0 0 0 0 0 54 0 0 0 8 16 % E
% Phe: 0 0 0 0 0 0 8 8 0 0 0 0 0 0 0 % F
% Gly: 8 8 0 0 0 16 8 16 8 0 0 0 8 0 8 % G
% His: 0 0 0 0 0 0 16 0 8 0 0 0 0 0 0 % H
% Ile: 0 8 16 0 0 0 0 0 0 0 0 0 0 8 8 % I
% Lys: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 24 0 62 77 8 8 24 0 0 0 0 47 0 77 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 8 0 0 0 8 0 0 8 0 0 0 8 0 8 % N
% Pro: 0 0 0 0 0 0 0 0 8 0 0 0 54 0 0 % P
% Gln: 0 0 0 0 8 0 0 0 0 8 0 8 0 0 0 % Q
% Arg: 47 0 0 0 77 8 31 0 47 8 0 16 0 0 0 % R
% Ser: 0 47 0 0 0 47 0 0 0 8 0 0 16 0 0 % S
% Thr: 0 0 0 0 0 8 0 0 8 0 0 8 8 0 0 % T
% Val: 0 0 8 0 0 0 0 0 0 8 70 0 0 0 8 % V
% Trp: 0 0 0 8 0 0 0 0 0 0 8 16 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 70 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _